Triethylamine → HCID 21539424, 화합물

HRID 1076198노트

반응식

HRID 1076198 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:6]=1[C:7]#[N:8].[CH3:13][N:14]=[C:15]=[O:16].C(N(CC)CC)C>CN(C)C=O>[C:7]([C:6]1[C:5]([C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][S:3][C:2]=1[NH:1][C:15]([NH:14][CH3:13])=[O:16])#[N:8]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 5968662-Amino-4-(1,1-dimethylethyl)-3-thiophenecarbonitrile

생성물 1

HCID 21539424HCID 21539424, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4 g 2-amino-3-cyano-4-t-butylthiophene, 1.27 g methyl isocyanate and 3 ml triethylamine in 20 ml dimethylformamide was heated at 130°C. for 3 hours and then allowed to stand at about 25°C. overnight. The dimethylformamide was removed by distillation and the residue was crystallized from ether to give the product, as a tan solid, m.p. 212°-214°C. The infrared spectrum of the product showed cyano absorption at 4.6 microns. Sulfur analysis for the product is tabulated in Table I.

후처리

  1. customThe dimethylformamide was removed by distillation
  2. customthe residue was crystallized from ether
  3. customto give the product
  4. customcyano absorption at 4.6 microns

출처 및 근거

ORD 기록
ord-29fe9d9ff3f94f46a5d89010d05c1bce
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03956315

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