Toluene → 4p-Chlorophenyl-5-methyl-2-pyrrolidinone

HRID 1076232

반응식

HRID 1076232 반응식
[N+:1]([CH2:4][CH3:5])([O-])=O.C(O[C:9](=[O:19])[CH:10]=[CH:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)C.[OH-].C[N+](C)(C)CC1C=CC=CC=1.C1(C)C=CC=CC=1>CO>[Cl:18][C:15]1[CH:14]=[CH:13][C:12]([CH:11]2[CH:4]([CH3:5])[NH:1][C:9](=[O:19])[CH2:10]2)=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 1140TolueneHCID 6587NitroethaneHCID 66854Benzyltrimethylammonium hydroxideHCID 2014712-Propenoic acid, 3-(4-chlorophenyl)-, ethyl ester

생성물 1

HCID 123953184p-Chlorophenyl-5-methyl-2-pyrrolidinone

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 150 g. (2 mole) of nitroethane, 105 g. (0.5 mole) of ethyl-p-chlorocinnamate and 6.6 g. of Triton B (a 35% solution of trimethyl-benzyl-ammonium hydroxide in methanol) is heated for 20 hours at 80°C. After the reaction has finished, toluene is added, washing is carried out with a saturated solution of sodium chloride and the organic solution is dried and evaporated to dryness and the residue is distilled. Yield: 80%; B.P.: 150°-155°C./0.3 mm.Hg.

후처리

  1. additionA mixture of 150 g
  2. washwashing
  3. customthe organic solution is dried
  4. customevaporated to dryness
  5. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-faaf505d44704321a69020ba2cb9a13a
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03956314

연결된 노트

불러오는 중…