Hydrochloric Acid → 1-Nitro-2-acetylthiomethyloxy propane

반응식

[N+:1]([CH2:4][CH:5]([OH:7])[CH3:6])([O-:3])=[O:2].C=O.Cl.ClC[O:13]CCl.[S:16]1[CH:20]=[CH:19]C=[C:17]1CC(O)=O>>[N+:1]([CH2:4][CH:5]([O:7][CH2:17][S:16][C:20](=[O:13])[CH3:19])[CH3:6])([O-:3])=[O:2]

참가 물질

반응물 5

HCID 313Hydrochloric Acid

HCID 712Formaldehyde

HCID 10967Bis(Chloromethyl) Ether

HCID 159702-Thiopheneacetic acid

HCID 955371-Nitropropan-2-ol

생성물 1

HCID 215405421-Nitro-2-acetylthiomethyloxy propane

실험 절차

A quantity of 206 grams of 1-nitro-2-propanol was chloromethylated with 60 grams paraformaldehyde and excess hydrogen chloride according to the procedure given in Example I. The crude chloromethylether resulting was reacted with 154 grams of thiolacetic acid and then 154 grams of pyridine and distilled in vacuo after workup as described in Example I to give 123 grams of 1-nitro-2-acetylthiomethyloxy propane; structure confirmed by spectral analysis.