Sodium hydride → HCID 20361951, 화합물

HRID 1076704노트

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HRID 1076704 반응식
[CH3:1][C:2]1[N:3]=[N:4][C:5](=[O:9])[C:6]=1[CH2:7][CH3:8].[H-].[Na+].[CH3:12][CH:13](Cl)[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1>CN(C)C=O>[CH3:1][C:2]1[NH:3][N:4]([CH:13]([CH3:12])[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[C:5](=[O:9])[C:6]=1[CH2:7][CH3:8]

참가 물질

5

반응물 3

HCID 24758Sodium hydrideHCID 1082961,2-Dichloro-4-(1-chloroethyl)benzeneHCID 54312548HCID 54312548, 화합물

생성물 1

HCID 20361951HCID 20361951, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
60 °C

실험 절차

25.2 g of 3-methyl-4-ethylpyrazol-5-one were added in portions to a suspension of 10.0 g (0.22 mol) of sodium hydride in 200 ml of absolute dimethylformamide. After the evolution of H2 had ceased, 41.8 g (0.2 mol) of α-methyl-3,4-dichlorobenzyl chloride were added dropwise to the reaction solution. The mixture was then stirred for 2 hours at 60°C, the solvent was distilled off in vacuo and the residue was taken up in water and acidified with dilute acetic acid. The crude product thereby obtained was recrystallized from ethanol.

후처리

  1. distillationthe solvent was distilled off in vacuo

출처 및 근거

ORD 기록
ord-eafebbc078bb4c6386b67798352a70f2
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03957814

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