Hydrochloric Acid → 2,7-Bis(4-aminobutyryl)thioxanthene Dihydrochloride

HRID 1076898

반응식

HRID 1076898 반응식
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([C:11]2[CH:24]=[CH:23][C:22]3[S:21][C:20]4[C:15](=[CH:16][C:17]([C:25](=[O:40])[CH2:26][CH2:27][CH2:28][N:29]5C(=O)C6=CC=CC=C6C5=O)=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])C(=O)C2=CC=CC=C12.C1(=O)N(CCCC([Cl:57])=O)C(=O)C2=CC=CC=C12.C1C2CC3C(=CC=CC=3)SC=2C=CC=1.[ClH:78]>C(O)(=O)C>[ClH:57].[ClH:78].[NH2:29][CH2:28][CH2:27][CH2:26][C:25]([C:17]1[CH:18]=[CH:19][C:20]2[S:21][C:22]3[C:13](=[CH:12][C:11]([C:9](=[O:10])[CH2:8][CH2:7][CH2:6][NH2:5])=[CH:24][CH:23]=3)[CH2:14][C:15]=2[CH:16]=1)=[O:40]

참가 물질

6

반응물 4

HCID 313Hydrochloric Acid2회HCID 67495ThioxantheneHCID 5948864-(1,3-Dioxoisoindolin-2-yl)butanoyl chlorideHCID 21538549HCID 21538549, 화합물

생성물 1

HCID 215385232,7-Bis(4-aminobutyryl)thioxanthene Dihydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2,7-Bis(4-phthalimidobutyryl)thioxanthene, prepared from 4-phthalimidobutyryl chloride and thioxanthene by the method of S.S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with hot glacial acetic acid after which concentrated HCl is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture. The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

후처리

  1. additionis added gradually
  2. temperatureThe mixture is heated
  3. stirringThe reaction mixture is stirred
  4. temperaturerefluxed for an additional 24 hours
  5. temperaturecooled

출처 및 근거

ORD 기록
ord-32bbde71d22946ac9780e9de7f260c7f
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03957988

연결된 노트

불러오는 중…