Xanthene → Xanthone

HRID 1076900

반응식

HRID 1076900 반응식
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=[O:22].[K+].[K+].[CH:32]1[C:45]2[CH2:44][C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[O:37][C:36]=2[CH:35]=[CH:34][CH:33]=1>C(O)(=O)C.C(O)(C)(C)C.O>[CH:32]1[C:45]2[C:44](=[O:22])[C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[O:37][C:36]=2[CH:35]=[CH:34][CH:33]=1

참가 물질

8

반응물 4

HCID 7107Xanthene2회HCID 24502Potassium DichromateHCID 24503Dichromate ionHCID 25408Sodium Dichromate2회

생성물 1

HCID 7020Xanthone

시약·촉매·용매 3

HCID 176Acetic Acid용매2회HCID 962Water용매HCID 6386tert-Butanol용매

실험 절차

The above oxidation reaction may be carried out using dichromate anion such as sodium dichromate or potassium dichromate as the oxidizing agent. The reaction will proceed in from 15 minutes to 6 hours at a temperature of from 80° to 120°C. The amount of oxidizing agent is limited to the stoichiometric quantity required for oxidation of the 9-methylene group of the xanthene derivative. Suitable solvents for this conversion are, for example, water, acetic acid, tert-butyl alcohol, and the like, or combinations of these solvents. For example, by combining three moles of the xanthene derivative, Formula II, dissolved in acetic acid with four moles of sodium dichromate and refluxing the mixture for 1 to 3 hours, the corresponding xanthen-9-one derivative, Formula III, can be obtained.

후처리

  1. customThe above oxidation reaction
  2. customThe reaction
  3. customwill proceed in from 15 minutes to 6 hours at a temperature of from 80° to 120°C
  4. temperaturerefluxing the mixture for 1 to 3 hours

출처 및 근거

ORD 기록
ord-c3c3123c34a842918312ec9639ac1e9c
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03957989

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