Hydrochloric Acid → HCID 21538576, 화합물

HRID 1076915

반응식

HRID 1076915 반응식
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([C:11]2[CH:24]=[CH:23][C:22]3[O:21][C:20]4[C:15](=[CH:16][C:17]([C:25](=[O:40])[CH2:26][CH2:27][CH2:28][N:29]5C(=O)C6=CC=CC=C6C5=O)=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])C(=O)C2=CC=CC=C12.C1(=O)N(CCCC([Cl:57])=O)C(=O)C2=CC=CC=C12.C1C2CC3C(=CC=CC=3)OC=2C=CC=1.[ClH:78]>C(O)(=O)C>[ClH:57].[ClH:78].[NH2:29][CH2:28][CH2:27][CH2:26][C:25]([C:17]1[CH:18]=[CH:19][C:20]2[O:21][C:22]3[C:13](=[CH:12][C:11]([C:9](=[O:10])[CH2:8][CH2:7][CH2:6][NH2:5])=[CH:24][CH:23]=3)[CH2:14][C:15]=2[CH:16]=1)=[O:40]

참가 물질

6

반응물 4

HCID 313Hydrochloric Acid2회HCID 7107XantheneHCID 5948864-(1,3-Dioxoisoindolin-2-yl)butanoyl chlorideHCID 21538574HCID 21538574, 화합물

생성물 1

HCID 21538576HCID 21538576, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

2,7-Bis(4-phthalimidobutyryl)xanthene, prepared from 4-phthalimidobutyryl chloride and xanthene by the method of S. S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with 700 ml. of hot glacial acetic acid after which 200 ml. of concentrated hydrochloric acid is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

후처리

  1. addition9, 945 (1966), is treated with 700 ml
  2. temperatureThe mixture is heated
  3. stirringis stirred
  4. temperaturerefluxed for an additional 24 hours
  5. temperaturecooled

출처 및 근거

ORD 기록
ord-48f747910c064377ac980362554069e3
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03957989

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