Sodium borohydride → HCID 68143930, 화합물

HRID 1077163노트

반응식

HRID 1077163 반응식
[CH2:1]([C@:4]12[CH2:12][CH2:11][C:10]3[C:13]4[CH:14]=[CH:15][C:16]([O:21][CH3:22])=[CH:17][C:18]=4[CH2:19][CH2:20][C:9]=3[C@@H:8]1[CH2:7][CH2:6][C:5]2=[O:23])[CH2:2][CH3:3].[BH4-].[Na+]>CO>[CH2:1]([C@:4]12[CH2:12][CH2:11][C:10]3[C:13]4[CH:14]=[CH:15][C:16]([O:21][CH3:22])=[CH:17][C:18]=4[CH2:19][CH2:20][C:9]=3[C@@H:8]1[CH2:7][CH2:6][C@@H:5]2[OH:23])[CH2:2][CH3:3]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 54182015(±)-3-Methoxy-13-propylgona-1,3,5(10),8-tetraen-17-one

생성물 1

HCID 68143930HCID 68143930, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Add 13β-propyl-3-methoxygona-1,3,5(10),8-tetraen-17-one (3.5 g.) to a solution of sodium borohydride (1.16 g.) in methanol (120 cc.). Heat the reaction mixture to reflux with stirring for 30 minutes. Concentrate the resulting solution, adjust its pH to 6 with aqueous acetic acid and filter off the resulting white precipitate which is the title product, (3.1 g.), m.p. 134°-8°; ultra-violet absorption peak at 278 mμ (ε15,350); infrared showed a band due to hydroxyl but no ketone present.

후처리

  1. temperatureHeat the reaction mixture
  2. temperatureto reflux
  3. concentrationConcentrate the resulting solution
  4. filtrationfilter off the resulting white precipitate which

출처 및 근거

ORD 기록
ord-3c5969ae87314b1c84ef31762a4adb85
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03959322

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