Dicyclohexylcarbodiimide → 2-(Pyrrolidin-1-yl)pyridine

HRID 1077381

반응식

HRID 1077381 반응식
C(O[C@H]1C[C@@H](O)C=C1)(=O)C.[CH2:11]1[CH2:16][CH2:15][CH:14]([N:17]=[C:18]=[N:19][CH:20]2[CH2:25][CH2:24][CH2:23]CC2)CC1>C(Cl)Cl>[N:19]1([C:18]2[CH:11]=[CH:16][CH:15]=[CH:14][N:17]=2)[CH2:20][CH2:25][CH2:24][CH2:23]1

참가 물질

4

반응물 2

HCID 10868DicyclohexylcarbodiimideHCID 98554984-Cyclopentene-1,3-diol, 1-acetate, (1R,3S)-rel-

생성물 1

HCID 110190202-(Pyrrolidin-1-yl)pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3.1 mmol of the cyclopentenol, 3.1 mmol of DCC and 0.1 mmol of PP are dissolved in CH2Cl2 in a 100 ml flask fitted with a CaCl2 tube, 3.1 mmol of the carboxylic acid are added at 0°-5° C. with ice cooling, and the mixture is stirred at room temperature for 24 hours. The precipitated urea is filtered off, the solvent is removed by evaporation, and the crude product is recrystallized a number of times from ethanol.

후처리

  1. customfitted with a CaCl2 tube
  2. filtrationThe precipitated urea is filtered off
  3. customthe solvent is removed by evaporation
  4. customthe crude product is recrystallized a number of times from ethanol

출처 및 근거

ORD 기록
ord-6af82f90d71247dcb7e0ca8bd70bc64b
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05543076

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