Phloretin → HCID 70181280, 화합물

HRID 1077675노트

반응식

HRID 1077675 반응식
[OH:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][CH2:7][C:8]([C:10]2[C:11](=[CH:13][C:14](=[CH:16][C:17]=2[OH:18])[OH:15])[OH:12])=[O:9])=[CH:4][CH:3]=1.[BH4-].[Na+].C(OCC)(=O)C>CO.O>[OH:1][CH:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][C:8]([C:10]2[C:17](=[CH:16][C:14](=[CH:13][C:11]=2[OH:12])[OH:15])[OH:18])=[O:9])=[CH:19][CH2:20]1

참가 물질

6

반응물 3

HCID 4788PhloretinHCID 8857Ethyl AcetateHCID 4311764Sodium borohydride

생성물 1

HCID 70181280HCID 70181280, 화합물수율 67.5%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Phloretin (25 mg) is dissolved in the minimum amount of methanol, diluted with water (3 ml) and treated with a slight excess of NaBH4. After 5 minutes the solution is carefully acidified, with ethyl acetate. The Organic phase is dried over Na2SO4 and evaporated to dryness to give 17 mg of dihydrophloretin as white powder, homogeneous on TLC analysis (silica gel, CHCl3 /MeOH/H2O 70:28:2).

후처리

  1. dry with materialThe Organic phase is dried over Na2SO4
  2. customevaporated to dryness

출처 및 근거

ORD 기록
ord-e6a356067c3c4397b72f113997f80cc2
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545399

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