Sodium Hydroxide → 4'-Methyl-biphenyl-3-carboxylic acid
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16]CC)=[O:15])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([OH:16])=[O:15])[CH:9]=2)=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a solution of ethyl 4'-methylbiphenyl-3-carboxylate (4.0 g) in ethanol (50 ml) was added a solution of 10 ml of 10% aqueous sodium hydroxide, and the mixture refluxed for 2 hours. Solvent was removed under reduced pressure, water added to the residue, and the solution filtered. The filtrate was acidified with dilute hydrochloric acid, and the white solid filtered off and dried under vacuum, yielding 2.4 g of 4'-methylbiphenyl-3-carboxylic acid m.p. 192° C.
후처리
- temperaturethe mixture refluxed for 2 hours
- customSolvent was removed under reduced pressure, water
- additionadded to the residue
- filtrationthe solution filtered
- filtrationthe white solid filtered off
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-caafe567a20a4754856bf9f188721866
- 출처 데이터셋
- uspto-grants-1996_08
- 특허 번호
- US05545645
반응 노트
불러오는 중…