Sodium Hydroxide → 4'-Methyl-biphenyl-3-carboxylic acid

HRID 1077829

반응식

HRID 1077829 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16]CC)=[O:15])[CH:9]=2)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([OH:16])=[O:15])[CH:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 107287544'-Methyl-biphenyl-3-carboxylic acid ethyl ester

생성물 1

HCID 27739784'-Methyl-biphenyl-3-carboxylic acid수율 67.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 4'-methylbiphenyl-3-carboxylate (4.0 g) in ethanol (50 ml) was added a solution of 10 ml of 10% aqueous sodium hydroxide, and the mixture refluxed for 2 hours. Solvent was removed under reduced pressure, water added to the residue, and the solution filtered. The filtrate was acidified with dilute hydrochloric acid, and the white solid filtered off and dried under vacuum, yielding 2.4 g of 4'-methylbiphenyl-3-carboxylic acid m.p. 192° C.

후처리

  1. temperaturethe mixture refluxed for 2 hours
  2. customSolvent was removed under reduced pressure, water
  3. additionadded to the residue
  4. filtrationthe solution filtered
  5. filtrationthe white solid filtered off
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-caafe567a20a4754856bf9f188721866
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545645

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