Ethyl 2-methylacetoacetate → 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one
반응식
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[NH:7])=[CH:4][CH:3]=1.[CH3:11][CH:12]([C:18]([CH3:20])=O)[C:13](OCC)=[O:14]>C(O)C>[CH3:11][C:12]1[C:13](=[O:14])[NH:7][C:6]([C:5]2[CH:9]=[CH:10][C:2]([CH3:1])=[CH:3][CH:4]=2)=[N:8][C:18]=1[CH3:20]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 4-methylbenzamidine (4.4 g) in 30 ml of ethanol was added ethyl 2-methylacetoacetate (6.1 g), and the mixture refluxed for 4 hours, giving a precipitate. The mixture was cooled to 0° C., the solid filtered off, washed with ethanol, and dried under reduced pressure, yielding 6 g of 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one, m.p. 250° C.
후처리
- temperaturethe mixture refluxed for 4 hours
- customgiving a precipitate
- filtrationthe solid filtered off
- washwashed with ethanol
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-409d113b6f914bff874dfd871b70319e
- 출처 데이터셋
- uspto-grants-1996_08
- 특허 번호
- US05545645
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