N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea → 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone

HRID 1077893노트

반응식

HRID 1077893 반응식
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])=[O:8])C>CO.O.Cl>[F:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[N:9]1[CH:4]=[CH:5][NH:6][C:7]1=[O:8]

참가 물질

5

반응물 1

HCID 19065111N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea

생성물 1

HCID 190650921-(2,4-difluorophenyl)-2(1H,3H)-imidazolone수율 89.4%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 962Water용매

실험 절차

This urea compound (37.5 g) was dissolved in a mixture of 560 ml of methanol and 280 ml of water, 300 ml of 0.48M hydrochloric acid was added thereto and the mixture was stirred at room temperature for three days. The reaction solution was concentrated under reduced pressure and the crystals separated out were washed with a mixture of water and methanol (5:1) to give 22.8 g of 1-(2,4-difluorophenyl)-2-(1H,3H)-imidazolone as a colorless powder.

후처리

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe crystals separated out
  4. washwere washed with a mixture of water and methanol (5:1)

출처 및 근거

ORD 기록
ord-fd1afeae18914c18ad6669ea4a3ee72f
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545652

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