1-Bromo-3-chloropropane → 1-N-[1-N-(3-chloropropyl)-piperidin-4-yl]-indole

HRID 1077931노트

반응식

HRID 1077931 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:23][CH2:24][CH2:25][Cl:26]>C(O)C>[Cl:26][CH2:25][CH2:24][CH2:23][N:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 80061-Bromo-3-chloropropane2회HCID 11430Potassium CarbonateHCID 140907551-(Piperidin-4-yl)-1H-indole

생성물 1

HCID 229072601-N-[1-N-(3-chloropropyl)-piperidin-4-yl]-indole수율 65%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 1-(piperidin-4-yl)-indole (100 mg, 0.5 mmol) in absolute ethanol (2 mL) was added anhydrous potassium carbonate (70 mg, 0.5 mmol) and 1-bromo-3-chloropropane (150 mg, 1 mmol). After stirring overnight additional 1-bromo-3-chloropropane (150 mg) was added and stirring continued for 2 hours. The mixture was evaporated; and the residue dissolved in methylene chloride and shaken with water. The organic solution was dried over anhydrous potassium carbonate and evaporated. The residue was chromatographed on silica gel with methylene chloride/ethanol (95:5) to give the title compound (90 mg, 65% yield).

후처리

  1. additionwas added
  2. customThe mixture was evaporated
  3. dissolutionand the residue dissolved in methylene chloride
  4. stirringshaken with water
  5. dry with materialThe organic solution was dried over anhydrous potassium carbonate
  6. customevaporated
  7. customThe residue was chromatographed on silica gel with methylene chloride/ethanol (95:5)

출처 및 근거

ORD 기록
ord-a7cdccc42e614c7e8f078cb53fa5b16f
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545636

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