Sodium Hydroxide → 2-(2-Aminophenoxy)benzoic acid

HRID 1077977노트

반응식

HRID 1077977 반응식
[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8].[OH-].[Na+]>CO.O>[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 16080835HCID 16080835, 화합물

생성물 1

HCID 214610602-(2-Aminophenoxy)benzoic acid

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

A mixture of Methyl 2-(2-aminophenoxy)benzoate (9.2 g, 0.038 mol) and sodium hydroxide (3.2 g, 0.08 mol) in 1:1 methanol/water (200 mL) was stirred under argon at room temperature for 3 h. The methanol was evaporated, the aqueous residue was acidified with dilute HCl, extracted with ethyl acetate, dried over anhydrous MgSO4, filtered, and evaporated to give the crude product which was purified by flash chromatography (silica gel, ethyl acetate/hexane/formic acid), and then recrystallized from ethyl acetate/hexane to give the title compound as a white crystalline solid; mp 150°-151° C.

후처리

  1. customThe methanol was evaporated
  2. extractionextracted with ethyl acetate
  3. dry with materialdried over anhydrous MgSO4
  4. filtrationfiltered
  5. customevaporated
  6. customto give the crude product which
  7. customwas purified by flash chromatography (silica gel, ethyl acetate/hexane/formic acid)
  8. customrecrystallized from ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-925c8c3f2ddd42c691e12134fefa79fc
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05545669

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