4-Chlorobenzaldehyde → 4-(4-Chlorophenyl)butan-1-amine

HRID 1078376노트

반응식

HRID 1078376 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[NH2:10][CH2:11][CH2:12][CH2:13]N1C=C(C)N=C1CC1C=CC=CC=1.[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][CH2:13][CH2:12][CH2:11][NH2:10])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 77264-ChlorobenzaldehydeHCID 4311764Sodium borohydrideHCID 194293561-(3-Aminopropyl)-2-benzyl-4-methylimidazole

생성물 1

HCID 107738224-(4-Chlorophenyl)butan-1-amine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In a similar manner to Example 35, a mixture of 4-chlorobenzaldehyde (5.6 g) and 1-(3-aminopropyl)-2-benzyl-4-methylimidazole (9.2 g) in ethanol (100 ml) was stirred and then reduced with sodium borohydride (1.6 g) to give 3-(2-benzyl-4-methylimidazol-1-yl)-[-(4-chlorobenzyl)propylamine, b.p. 190°-200° C. (0.04 mmHg). Glc and 1H nmr indicated that the product contained 21% of 3-(2-benzyl-5-methylimidazol-1-yl)-N-(4-chlorobenzyl)propylamine.

출처 및 근거

ORD 기록
ord-db6e93efa3e549cc86c6f1e4e07fd3eb
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05547972

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