2-Methylimidazole → N-[1-(4-chlorophenyl)-1-methylethyl]-3-(2-methylimidazol-1-yl)propionamide

반응식

[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[H-].[Na+].Cl[CH2:10][CH2:11][C:12]([NH:14][C:15]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)([CH3:17])[CH3:16])=[O:13]>C1COCC1>[Cl:24][C:21]1[CH:20]=[CH:19][C:18]([C:15]([NH:14][C:12](=[O:13])[CH2:11][CH2:10][N:3]2[CH:4]=[CH:5][N:6]=[C:2]2[CH3:1])([CH3:17])[CH3:16])=[CH:23][CH:22]=1

참가 물질

실험 절차

In a similar manner to Example 52c, a mixture of 2-methylimidazole (1.3 g) and sodium hydride (0.63 g, 60% dispersion) in THF (35 ml) was treated with a mixture of 3-chloro-N-[1-(4-chlorophenyl)-1-methylethyl]propionamide (4.0 g) in THF (15 ml) to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(2-methylimidazol-1-yl)propionamide as an oil which was used directly in part (b) below.