4'-Hydroxyacetophenone → 2-Bromo-1-(4-hydroxyphenyl)ethanone

HRID 10787

반응식

HRID 10787 반응식
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)=[O:3].[Br:11]Br>O1CCOCC1>[Br:11][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)=[O:3]

참가 물질

4

반응물 2

HCID 74694'-HydroxyacetophenoneHCID 24408Bromine

생성물 1

HCID 49642-Bromo-1-(4-hydroxyphenyl)ethanone수율 44%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of 4-hydroxyacetophenone (2.5 g, 18.3 mmol) (Aldrich) in dioxane (10 mL) was added dropwise a solution of bromine (3.22 g, 20.1 mmol) in dioxane (20 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was recrystalized from methanol to provide 2-bromo-1-(4-hydroxyphenyl)ethanone (1.73 g, 44% yield).

후처리

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was recrystalized from methanol

출처 및 근거

ORD 기록
ord-1467451901b34110b095a0f9bc4d4385
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094896B2

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