Hydrochloric Acid → HCID 86749750, 화합물

HRID 1078718노트

반응식

HRID 1078718 반응식
C(OC([N:8]1[CH2:12][C@H:11]([O:13][Si](C(C)(C)C)(C)C)[CH2:10][C@H:9]1[C:21](=[O:27])[CH2:22][C:23](=[O:26])[NH:24][CH3:25])=O)(C)(C)C.[ClH:28]>CO>[ClH:28].[OH:13][C@H:11]1[CH2:12][NH:8][C@H:9]([C:21](=[O:27])[CH2:22][C:23](=[O:26])[NH:24][CH3:25])[CH2:10]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22865011HCID 22865011, 화합물

생성물 1

HCID 86749750HCID 86749750, 화합물수율 62%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[2-(N-methylcarbamoyl)-1-oxoethyl]pyrrolidine (2.07 g, 5.3 mmol) in methanol (10 ml) was added a 5.5N hydrogen chloride--methanol solution (6 ml, 33 mmol). The mixture was stirred at room temperature for 6 h. The reaction solution was concentrated in vacuo. Tetrahydrofuran and ethanol were added to the obtained residue, and the precipitate was collected by filtration and washed with ethanol to obtain (2S,4R)-4-hydroxy-2-[2-(N-methylcarbamoyl)-1-oxoethyl]pyrrolidine monohydrochloride (737 mg, yield: 62%).

후처리

  1. concentrationThe reaction solution was concentrated in vacuo
  2. additionTetrahydrofuran and ethanol were added to the obtained residue
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with ethanol

출처 및 근거

ORD 기록
ord-67a4d905d8a94c0ea3c6fe07db6b2ca8
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05550121

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