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Methyl Acetate → (2S,4R)-N-tert-Butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[1-hydroxy-2-(methoxycarbonyl)ethyl]pyrrolidine

HRID 1078721
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HRID 1078721 반응식
C[Si](C)(C)[N-][Si](C)(C)C.[Na+].[C:11]([O:14][CH3:15])(=[O:13])[CH3:12].[C:16]([O:20][C:21]([N:23]1[CH2:29][C@H:28]([O:30][Si:31]([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:33])[CH3:32])[CH2:27][C@H:24]1[CH:25]=[O:26])=[O:22])([CH3:19])([CH3:18])[CH3:17].[Cl-].[NH4+]>O1CCCC1>[C:16]([O:20][C:21]([N:23]1[CH2:29][C@H:28]([O:30][Si:31]([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:33])[CH3:32])[CH2:27][C@H:24]1[CH:25]([OH:26])[CH2:12][C:11]([O:14][CH3:15])=[O:13])=[O:22])([CH3:19])([CH3:18])[CH3:17]
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참가 물질

6

반응물 4

HCID 6584Methyl AcetateHCID 25517Ammonium ChlorideHCID 2724254Sodium bis(trimethylsilyl)amideHCID 10969557tert-Butyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-formylpyrrolidine-1-carboxylate

생성물 1

HCID 57107882(2S,4R)-N-tert-Butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[1-hydroxy-2-(methoxycarbonyl)ethyl]pyrrolidine수율 94.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

To tetrahydrofuran (5 ml) were successively dropwise added a 1.0M sodium hexamethyldisilazide--tetrahydrofuran solution (0.910 ml, 0.910 mmol) and methyl acetate (72.0 μl) at -78° C. The mixture was stirred for 30 minutes, and a tetrahydrofuran solution of (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxyprolinal (200 mg, 0.607 mmol) was added thereto at the same temperature. This solution was stirred for 30 minutes. Saturated aqueous ammonium chloride was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was removed in vacuo. The residue was purified by silica gel column chromatography (heptane-ethyl acetate=3:1) to give the title compound [232 mg, yield: 94.7%; (R)-isomer (polar compound):(S)-isomer (less polar compound)=6.27:1].

후처리

  1. customat -78° C
  2. stirringThis solution was stirred for 30 minutes
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with saturated aqueous sodium chloride
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was removed in vacuo
  7. customThe residue was purified by silica gel column chromatography (heptane-ethyl acetate=3:1)

출처 및 근거

ORD 기록
ord-cfc2a7c19b864fce8883959ad68c5f3e
출처 데이터셋
uspto-grants-1996_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05550121

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