Acetic Acid → 2-Ethyl-4-hydroxy-3-methylcyclopent-2-en-1-one

HRID 1079019

반응식

HRID 1079019 반응식
[CH3:1][C:2]1[O:6][C:5]([CH:7](O)[CH2:8][CH3:9])=[CH:4][CH:3]=1.[OH-].[Na+].C(O)(=[O:15])C.[Cl-].[Na+]>O.C(O)(=O)C>[OH:15][CH:3]1[CH2:4][C:5](=[O:6])[C:7]([CH2:8][CH3:9])=[C:2]1[CH3:1]

참가 물질

7

반응물 4

HCID 176Acetic AcidHCID 5234Sodium ChlorideHCID 14798Sodium Hydroxide2회HCID 14570731(2-Methyl-5-furanyl)propanol

생성물 1

HCID 229084112-Ethyl-4-hydroxy-3-methylcyclopent-2-en-1-one수율 52%

시약·촉매·용매 2

HCID 176Acetic Acid촉매HCID 962Water용매

실험 절차

A mixed solution of 28.97 g of the 1-(5-methyl-2-furyl)propanol thus obtained, 0.394 g of 50% aqueous acetic acid, 0.394 g of a 23% (w/v) sodium hydroxide solution in 579.4 g of water was heated and refluxed at the constant pH of 5.70 to 5.85 for 38 hours. After the mixed solution was cooled to the room temperature, a 23% (w/v) sodium hydroxide solution was added to the mixed solution to adjust the pH of the solution to 8.0 to 8.2, and then refluxed for three hours. A 50% acetic acid solution was added to the refluxing solution to adjust the pH to 6.0 to 6.5. The reaction solution was then cooled to the room temperature, mixed with 300 g of sodium chloride, and extracted three times with 500 ml of diethyl ether. The combined ether layer was washed twice with a saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure, the residue was distilled, and a distillate fraction of 157° to 162° C. at 19 mmHg was collected to yield 15 g of (RS)-4-hydroxy-3-methyl-2-ethylcyclopent-2-en-1-one. Yield 52%

후처리

  1. temperaturerefluxed at the constant pH of 5.70 to 5.85 for 38 hours
  2. temperaturerefluxed for three hours
  3. temperatureThe reaction solution was then cooled to the room temperature
  4. extractionextracted three times with 500 ml of diethyl ether
  5. washThe combined ether layer was washed twice with a saturated sodium chloride solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customAfter removal of the solvent under reduced pressure
  8. distillationthe residue was distilled
  9. distillationa distillate fraction of 157° to 162° C. at 19 mmHg was collected

출처 및 근거

ORD 기록
ord-72373786478d49ec832f7b2ea1e5e712
출처 데이터셋
uspto-grants-1996_08
특허 번호
US05550258

연결된 노트

불러오는 중…