Hydrochloric Acid → 4-(Piperidin-1-yl)aniline dihydrochloride

HRID 1079393

반응식

HRID 1079393 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-])=O.[ClH:16]>CO.[Pd]>[ClH:16].[ClH:16].[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 81049Piperidine, 1-(4-nitrophenyl)-

생성물 1

HCID 233669404-(Piperidin-1-yl)aniline dihydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of N-(4-nitrophenyl)piperidine (12 g) in methanol (50 ml) was added conc. hydrochloric acid (12 ml) and, by using 10% palladium/carbon as a catalyst, catalytic reduction was conducted at normal temperature and normal pressure. After completion of the reaction, the catalyst was removed and the solvent was distilled off. To the residue was added ethyl ether which was filtered off to obtain N-(4-aminophenyl)piperidine dihydrochloride (13.7 g) as a colorless solid.

후처리

  1. customAfter completion of the reaction
  2. customthe catalyst was removed
  3. distillationthe solvent was distilled off
  4. additionTo the residue was added ethyl ether which
  5. filtrationwas filtered off

출처 및 근거

ORD 기록
ord-a5f5f430f6224521ad1d3827cde920c7
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580883

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