Hydrochloric Acid → 1-(3-Aminophenyl)piperidine dihydrochloride

HRID 1079398노트

반응식

HRID 1079398 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[ClH:16]>CO.[Pd]>[ClH:16].[ClH:16].[NH2:1][C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 147652751-(3-Nitrophenyl)piperidine

생성물 1

HCID 233669441-(3-Aminophenyl)piperidine dihydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of N-(3-nitrophenyl)piperidine (12 g) in methanol (50 ml) was added conc. hydrochloric acid (12 ml) and, by using 10% palladium/carbon as a catalyst, catalytic reduction was conducted at normal temperature under normal pressure. After completion of the reaction, the catalyst was removed and the solvent was distilled off. Ethyl ether was added to the residue and the mixture was filtered off to obtain N-(3-aminophenyl)piperidine dihydrochloride (13.2 g) as a colorless solid.

후처리

  1. customAfter completion of the reaction
  2. customthe catalyst was removed
  3. distillationthe solvent was distilled off
  4. additionEthyl ether was added to the residue
  5. filtrationthe mixture was filtered off

출처 및 근거

ORD 기록
ord-d3a17d2545f9416e8816ac7874cbd5ba
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580883

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