Hydrochloric Acid → 4-(2-Methyl-4-nitrophenoxy)piperidine--hydrogen chloride (1/1)

HRID 1079401노트

반응식

HRID 1079401 반응식
C([N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:12]=2[CH3:20])[CH2:6][CH2:5]1)(=O)C.[ClH:21].C(O)C>O>[ClH:21].[N+:17]([C:14]1[CH:15]=[CH:16][C:11]([O:10][CH:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[C:12]([CH3:20])[CH:13]=1)([O-:19])=[O:18]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 23366939HCID 23366939, 화합물

생성물 1

HCID 233669804-(2-Methyl-4-nitrophenoxy)piperidine--hydrogen chloride (1/1)

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 1-acetyl-4-(4-nitro-2-methylphenyloxy)piperidine (11.8 g) were added conc. hydrochloric acid (15 ml), ethanol (15 ml) and water (15 ml) and the mixture was heated under reflux overnight. The reaction mixture was concentrated under reduced pressure, the residue thus obtained was washed with ethyl ether and crystals were filtered off to obtain 4-(4-nitro-2-methylphenyloxy)piperidine hydrochloride (8.3 g) as white crystals, m.p. 204°-226° C.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux overnight
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue thus obtained
  5. washwas washed with ethyl ether and crystals
  6. filtrationwere filtered off

출처 및 근거

ORD 기록
ord-0749b75cb7a3407a8d78e2f757b2fc54
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05580883

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