Sodium borohydride → Methyl thien-2-yl-hydroxyacetate

HRID 1080710노트

반응식

HRID 1080710 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:11])[C:7]([O:9][CH3:10])=[O:8].[BH4-].[Na+]>C(O)C.O>[OH:11][CH:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[C:7]([O:9][CH3:10])=[O:8]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 11217486Methyl alpha-oxo-2-thiopheneacetate

생성물 1

HCID 13682356Methyl thien-2-yl-hydroxyacetate수율 88.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a stirred solution of methyl 2-thiopheneglyoxylate (1.01 g) in ethanol (20 ml) in an ice bath was added sodium borohydride (0.113 g) in 1 ml of water, and the mixture was stirred for 10 minutes. The reaction was quenched with aqueous acetic acid and the mixture was partitioned between methylene chloride and water. The organic extract was washed with brine, dried (sodium sulfate) and evaporated to give methyl α-hydroxy-2-thienylacetate as an oil (0.903 g).

후처리

  1. customThe reaction was quenched with aqueous acetic acid
  2. customthe mixture was partitioned between methylene chloride and water
  3. extractionThe organic extract
  4. washwas washed with brine
  5. dry with materialdried (sodium sulfate)
  6. customevaporated

출처 및 근거

ORD 기록
ord-657ee4f9087f4328a004c25ec7dafb83
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05583147

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