Sodium hydride → HCID 54135753, 화합물

반응식

Cl[C:2]1[CH:7]=[CH:6][N+:5]([O-:8])=[C:4]([CH3:9])[C:3]=1[CH3:10].[SH:11][CH2:12][CH2:13][C:14]1[S:18][CH:17]=[N:16][C:15]=1[CH3:19].[H-].[Na+]>>[CH3:9][C:4]1[C:3]([CH3:10])=[C:2]([S:11][CH2:12][CH2:13][C:14]2[S:18][CH:17]=[N:16][C:15]=2[CH3:19])[CH:7]=[CH:6][N+:5]=1[O-:8]

참가 물질

반응물 3

HCID 24758Sodium hydride

HCID 98774464-Chloro-2,3-dimethyl-1-oxidopyridin-1-ium

HCID 186900032-(4-Methyl-1,3-thiazol-5-yl)ethane-1-thiol

생성물 1

HCID 54135753HCID 54135753, 화합물수율 79%

실험 절차

Following the procedure described in Example Aa), the reaction of 4-chloro-2,3-dimethylpyridine N-oxide with 5-(2-mercaptoethyl)-4-methylthiazole in the presence of sodium hydride gives 2,3-dimethyl-4-[2-(4-methyl-5-thiazolyl)-ethylthio]pyridine N-oxide; m.p.: 135°-137° C (yield: 79%).

출처 및 근거

ORD 기록: ord-527e5380bdce41c7beddefbf8ed0949e
출처 데이터셋: uspto-grants-1996_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05587389

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