Acetone → 2,5-Difluoroanisole

HRID 1081937노트

반응식

HRID 1081937 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[OH:9].[CH3:10]C(C)=O.C(=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[O:9][CH3:10]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 949522,5-Difluorophenol

생성물 1

HCID 27249892,5-Difluoroanisole

시약·촉매·용매 1

HCID 962Water용매

실험 절차

35.0 g of the product of Step A, 350 ml of acetone, 44.6 g of potassium carbonate and 40.7 g of dimethyl sulfate (neutralized on potassium bicarbonte) and was allowed to returnto ambient temperature. Water was added and extraction was carried out with ether. The extracts were washed, dried and concentrated to dryness under reduced pressure to obtain 39.8 g of the desired product.

후처리

  1. customto returnto ambient temperature
  2. extractionextraction
  3. washThe extracts were washed
  4. customdried
  5. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-119a67992fbe4cbe9939be9246da97a8
출처 데이터셋
uspto-grants-1996_12
특허 번호
US05587372

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