1-Methyl-2-(propan-2-yl)-1H-imidazole → HCID 178468653, 화합물

HRID 1082750

반응식

HRID 1082750 반응식
CC(C)c1nccn1C.CCOC(=O)c1cc(Br)cn1CC>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].COc1ccc(OC)c(P(C2CCCCC2)C2CCCCC2)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.[K+]>CCOC(=O)c1cc(-c2cnc(C(C)C)n2C)cn1CC

참가 물질

8

반응물 2

HCID 130729731-Methyl-2-(propan-2-yl)-1H-imidazoleHCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 178468653HCID 178468653, 화합물수율 1.83%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 25112535Brettphos촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

반응 조건

온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-73489ea3f7354e8c96c06fed4b1786ee
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
원본 링크
출처 보기

연결된 노트

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