2-Acetyl-5-bromothiophene → HCID 178466101, 화합물

HRID 1082787노트

반응식

HRID 1082787 반응식
CC(=O)c1ccc(Br)s1.CC(C)c1nccn1C>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CP(c1ccccc1)c1ccccc1.[K+]>CC(=O)c1ccc(-c2cnc(C(C)C)n2C)s1

참가 물질

8

반응물 2

HCID 793352-Acetyl-5-bromothiopheneHCID 130729731-Methyl-2-(propan-2-yl)-1H-imidazole

생성물 1

HCID 178466101HCID 178466101, 화합물수율 93.57%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 73879Methyldiphenylphosphine촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

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온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-03f66a0b86d3497eacefa167ca4e72bf
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
원본 링크
출처 보기

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