1-Methyl-2-(propan-2-yl)-1H-imidazole → HCID 178440022, 화합물

HRID 1082825노트

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HRID 1082825 반응식
CC(C)(C)NS(=O)(=O)c1cncc(Br)c1.CC(C)c1nccn1C>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CN(C)c1ccccc1-c1ccccc1P(C1CCCCC1)C1CCCCC1.[K+]>CC(C)c1ncc(-c2cncc(S(=O)(=O)NC(C)(C)C)c2)n1C

참가 물질

8

반응물 2

HCID 130729731-Methyl-2-(propan-2-yl)-1H-imidazoleHCID 617949515-Bromo-N-tert-butylpyridine-3-sulfonamide

생성물 1

HCID 178440022HCID 178440022, 화합물수율 75.29%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 27342172-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

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온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-86e71f1c4ea0475f9cdeb4904e9d2cb7
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
원본 링크
출처 보기

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