1-Methyl-1H-imidazole-4-carbonitrile → ethyl 4-(4-cyano-1-methyl-1H-imidazol-5-yl)-1-ethyl-1H-pyrrole-2-carboxylate

HRID 1082893

반응식

HRID 1082893 반응식
CCOC(=O)c1cc(Br)cn1CC.Cn1cnc(C#N)c1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].CN(C)c1ccc(P(C2CCCCC2)C2CCCCC2)cc1.[K+]>CCOC(=O)c1cc(-c2c(C#N)ncn2C)cn1CC

참가 물질

8

반응물 2

HCID 27951151-Methyl-1H-imidazole-4-carbonitrileHCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 117937785ethyl 4-(4-cyano-1-methyl-1H-imidazol-5-yl)-1-ethyl-1H-pyrrole-2-carboxylate수율 10.35%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 142458Benzenamine, 4-(dicyclohexylphosphino)-N,N-dimethyl-촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

반응 조건

온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-0b71c7a1c6dd4a6a8cf4ff4fa338d963
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
원본 링크
출처 보기

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