홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1-Methyl-1H-imidazole-4-carbonitrile → ethyl 4-(4-cyano-1-methyl-1H-imidazol-5-yl)-1-ethyl-1H-pyrrole-2-carboxylate

HRID 1082904
노트
인쇄 미리보기

반응식

HRID 1082904 반응식
CCOC(=O)c1cc(Br)cn1CC.Cn1cnc(C#N)c1>C=C[CH2][Pd][Cl].C=C[CH2][Pd][Cl].CC(=O)N(C)C.CC(C)(C)C(=O)[O-].FC(F)(F)c1cc(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc(C(F)(F)F)c1.[K+]>CCOC(=O)c1cc(-c2c(C#N)ncn2C)cn1CC
참가 물질반응 조건후처리출처 및 근거반응 노트

참가 물질

8

반응물 2

HCID 27951151-Methyl-1H-imidazole-4-carbonitrileHCID 78918332Ethyl 4-bromo-1-ethyl-1H-pyrrole-2-carboxylate

생성물 1

HCID 117937785ethyl 4-(4-cyano-1-methyl-1H-imidazol-5-yl)-1-ethyl-1H-pyrrole-2-carboxylate수율 1.62%

시약·촉매·용매 5

HCID 23662159Potassium Trimethylacetate시약HCID 2778032Tris[3,5-bis(trifluoromethyl)phenyl]phosphine촉매HCID 178455864HCID 178455864, 화합물촉매HCID 31374Dimethylacetamide용매3회HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenyl내부 표준

반응 조건

온도
120 °C

후처리

  1. temperatureCool to room temperature
  2. addition기록된 절차가 없습니다
  3. aliquot기록된 절차가 없습니다
  4. filtrationFilter into HPLC analysis plate · liquid/mobile 상 유지
  5. washwash filter with 400 microliter of acetonitrile/water (4:1)

출처 및 근거

ORD 기록
ord-88fdef6e132a47afb25608f9b8082d81
출처 데이터셋
Pd-catalyzed C-H arylation of imidazole with aryl bromide
DOI
10.26434/chemrxiv
원본 링크
출처 보기

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건후처리출처 및 근거반응 노트