Isophthalaldehyde → 3-(2-(6-Phenylpyridin-2-yl)ethenyl)benzaldehyde

HRID 1084425

반응식

HRID 1084425 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:3]=1.[CH:14](=O)[C:15]1[CH:22]=[CH:21][CH:20]=[C:17]([CH:18]=[O:19])[CH:16]=1>[Cl-].[Zn+2].[Cl-]>[C:8]1([C:4]2[N:3]=[C:2]([CH:1]=[CH:14][C:15]3[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=3)[CH:18]=[O:19])[CH:7]=[CH:6][CH:5]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 34777IsophthalaldehydeHCID 27628852-Methyl-6-phenylpyridine

생성물 1

HCID 539539623-(2-(6-Phenylpyridin-2-yl)ethenyl)benzaldehyde

시약·촉매·용매 1

HCID 3007855Zincchloride촉매

반응 조건

온도
160 °C

실험 절차

A mixture of 2-methyl-6-phenylpyridine (525 mg) (step 2), isophthalaldehyde (630 mg) and dry zinc chloride (40 mg) was heated at 160° C. under N2 for 3 hours. The resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer was washed with H2O (10 cc), brine and solvent as removed in vacuo. The residue was purified by chromatography to afford the title compound.

후처리

  1. customThe resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer
  2. washwas washed with H2O (10 cc), brine and solvent
  3. customas removed in vacuo
  4. customThe residue was purified by chromatography

출처 및 근거

ORD 기록
ord-f283381da93346dab8a20399803753e3
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05004743

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