Water → 4-(Trifluoromethoxy)benzenemethanol

HRID 1084788

반응식

HRID 1084788 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8]([F:19])([F:18])[O:9][C:10]1[CH:17]=[CH:16][C:13]([C:14]#N)=[CH:12][CH:11]=1.[OH2:20].[OH-].[Na+]>C(OCC)C>[F:7][C:8]([F:19])([F:18])[O:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][OH:20])=[CH:12][CH:11]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 676214-(Trifluoromethoxy)benzonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 1371844-(Trifluoromethoxy)benzenemethanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of lithium aluminium hydride in diethyl ether (1.0M, 69.4 ml) was added dropwise to a stirred solution of 4-(trifluoromethoxy)benzonitrile (6.0 g) in diethyl ether (120 ml) over 15 minutes. Water (2.66 ml), 10% sodium hydroxide solution (2.66 ml) and water (7.98 ml) were then added successively, dropwise. The precipitated solid was filtered off and washed with diethyl ether. The filtrate and washings were combined and evaporated under reduced pressure to give 4-(trifluoromethoxy)benzyl alcohol, N.M.R. in deuteriochloroform: δ2.3 (1H,s), 4.65 (2H,s), 7.2 (2H,d), 7.35 (2H,d).

후처리

  1. filtrationThe precipitated solid was filtered off
  2. washwashed with diethyl ether
  3. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-8a6c4f1d475c48e5b81e3b4d865e66ef
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05006543

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