Triethylamine → Dimethyl 3-(4-methoxycarbonylphenyl)-2-isoxazolin-5-ylphosphonate

HRID 1084803

반응식

HRID 1084803 반응식
ON[C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1.ClN1[C:18](=[O:19])[CH2:17][CH2:16]C1=O.C([P:23](=[O:28])([O:26][CH3:27])[O:24][CH3:25])=C.C([N:31](CC)CC)C>>[CH3:10][O:9][C:7]([C:6]1[CH:5]=[CH:4][C:3]([C:16]2[CH2:17][CH:18]([P:23](=[O:28])([O:26][CH3:27])[O:24][CH3:25])[O:19][N:31]=2)=[CH:12][CH:11]=1)=[O:8]

참가 물질

5

반응물 4

HCID 8471TriethylamineHCID 31398ChlorosuccinimideHCID 78376Dimethyl vinylphosphonateHCID 11137507Methyl 4-(hydroxyamino)benzoate

생성물 1

HCID 14460581Dimethyl 3-(4-methoxycarbonylphenyl)-2-isoxazolin-5-ylphosphonate

실험 절차

Reaction of 80.6 g (0.45 mol) of methyl 4-hydroxyaminobenzoate, 67.0 g (0.5 mol) of N-chlorosuccinimide, 61.25 g (0.45 mol) of dimethyl vinylphosphonate and 78.45 ml (0.56 mol) of triethylamine as in Example 1 provides, after recrystallization from tert.butyl methyl ether, 115.2 g of pure product of melting point 93° C.

후처리

  1. customprovides
  2. customafter recrystallization from tert.butyl methyl ether, 115.2 g of pure product of melting point 93° C.

출처 및 근거

ORD 기록
ord-02d9460b3412401a8a35929ddf9a6867
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05006515

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