L-Lysine → HCID 67924379, 화합물

HRID 1084823노트

반응식

HRID 1084823 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14])=[O:9].[NH2:20][C@H:21]([C:27]([OH:29])=[O:28])[CH2:22][CH2:23][CH2:24][CH2:25][NH2:26]>O1CCCC1.O>[NH2:20][C@H:21]([C:27]([OH:29])=[O:28])[CH2:22][CH2:23][CH2:24][CH2:25][NH2:26].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14])=[O:9]

참가 물질

5

반응물 2

HCID 5962L-LysineHCID 3063368HCID 3063368, 화합물

생성물 1

HCID 67924379HCID 67924379, 화합물수율 67.5%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-[3-(2-thienyl)acrylamido]benzoic acid (500 mg, 1.8 mmol) in tetrahydrofuran (5 ml) was added L-lysine (267 mg, 1.8 mmol) dissolved in water (3 ml). After stirring the mixture at room temperature for 1.5 hour, the solvent was removed, and the residue was triturated with ether to give crystals. After filtering and drying, the crystals were dissolved in water, the insoluble matter was removed and water was distilled off. The residue was crystallized with ether to give pale yellow solids of the desired L-lysine salt (510 mg, yield, 66%). m.p., 208°-213° C.

후처리

  1. customthe solvent was removed
  2. customthe residue was triturated with ether
  3. customto give crystals
  4. filtrationAfter filtering
  5. customdrying
  6. dissolutionthe crystals were dissolved in water
  7. customthe insoluble matter was removed
  8. distillationwater was distilled off
  9. customThe residue was crystallized with ether

출처 및 근거

ORD 기록
ord-ec83b9e36015448fbdc19cee50eb30e7
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05006548

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