Dimethylformamide → HCID 1226728, 화합물

HRID 1084824노트

반응식

HRID 1084824 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14])=[O:9].[C:20](=O)([O-])[O-].[K+].[K+].CN(C)C=O.CI>CC(C)=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([O:15][CH3:20])=[O:14])=[O:9]

참가 물질

6

반응물 4

HCID 6228Dimethylformamide2회HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 3063368HCID 3063368, 화합물

생성물 1

HCID 1226728HCID 1226728, 화합물수율 74.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a suspension of 2-[3-(2-thienyl)acrylamido]benzoic acid (273 mg, 1 mmol) in dry acetone (2 ml) were added potassium carbonate (194 mg, 1.4 mmol) and dry dimethylformamide (1 ml). The mixture was treated with methyl iodide (199 mg, 1.4 mmol) and dry dimethylformamide (2 ml) and stirred at room temperature for 3 hours. The reaction mixture was poured into ice water, the precipitated solid was collected on a filter by suction, dried, and recrystallized from the mixed solvent of methanol and water to give pale yellow crystals of the desired compound (213 mg, yield, 74%). m.p., 126°-127° C.

후처리

  1. customthe precipitated solid was collected on
  2. filtrationa filter by suction
  3. customdried
  4. customrecrystallized from the mixed solvent of methanol and water

출처 및 근거

ORD 기록
ord-bbf74cbe8e1d4834beecf124acec8e88
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05006548

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