Dimethylformamide → HCID 898498, 화합물

HRID 1084825노트

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HRID 1084825 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([OH:15])=[O:14])=[O:9].C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.[CH2:31](I)[CH3:32]>CC(C)=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([NH:10][C:11]1[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=1[C:13]([O:15][CH2:31][CH3:32])=[O:14])=[O:9]

참가 물질

6

반응물 4

HCID 6228Dimethylformamide2회HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 3063368HCID 3063368, 화합물

생성물 1

HCID 898498HCID 898498, 화합물수율 65.4%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
60 °C

실험 절차

To a suspension of 2-[3-(2-thienyl)acrylamido]benzoic acid (273 mg, 1 mmol) in acetone (2 ml) were added potassium carbonate (194 mg, 1.4 mmol) and dry dimethylformamide (1 ml). To the resulting solution, ethyl iodide (218 mg, 1.4 mmol) and dry dimethylformamide (2 ml) were added and the mixture was stirred at 60° C. for 1 hour. The reaction mixture was poured into ice water. The precipitated solid was collected by suction, and recrystallized from methanol to give pale yellow crystals of the desired compound (197 mg, yield, 65%). m.p., 120°-122° C.

후처리

  1. customThe precipitated solid was collected by suction
  2. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-51c3f0397e8f469bb8be3e0dffc61165
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05006548

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