Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
8-Hydroxyquinoline → Acetamide, N-(2-methoxyphenyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 8-Hydroxyquinoline | HCID 1923 | — |
| 반응물 | 2'-Bromoacetanilide | HCID 136416 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 촉매 | Copper | HCID 23978 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Acetamide, N-(2-methoxyphenyl)- | HCID 7135 | 866.6% |
반응 단계
2.3 ml of a 28% solution of sodium methoxide in methanol and 63 mg of copper powder were added to 40 ml of methanol, and the mixture was heated under reflux for 1 hour. Then, 145 mg of 8-hydroxyquinoline and 2.14 g of 2-bromo-1-acetylaminobenzene were added thereto, and the mixture was heated under reflux for 3 hours. The reaction mixture was treated in a usual manner, to obtain 1.43 g (yield: 87%) of the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05006660 |
| 출처 데이터셋 | uspto-grants-1991_04 |
| ORD ID | ord-e8e0abe2a99d4208807a76251ef34c06 |
| 출처 메모 | uspto-grants-1991_04 |