Prostaglandin D2 → Arachidonic Acid

HRID 1085044

반응식

HRID 1085044 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6](O)/[CH:7]=[CH:8]/[C@H:9]1[C:13](=O)[CH2:12][C@H:11](O)[C@@H:10]1[CH2:16]/[CH:17]=[CH:18]\[CH2:19][CH2:20][CH2:21][C:22]([OH:24])=[O:23].CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)C(=O)C[C@H]1O.CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C[C@H]1O.CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](CC(CCCCC(O)=O)=O)[C@@H](O)C[C@H]1O>>[C:22]([OH:24])(=[O:23])[CH2:21][CH2:20][CH2:19]/[CH:18]=[CH:17]\[CH2:16]/[CH:10]=[CH:11]\[CH2:12]/[CH:13]=[CH:9]\[CH2:8]/[CH:7]=[CH:6]\[CH2:5][CH2:4][CH2:3][CH2:2][CH3:1]

참가 물질

5

반응물 4

HCID 448457Prostaglandin D2HCID 5280360Prostaglandin E2HCID 5280363DinoprostHCID 52808886-Ketoprostaglandin F1 alpha

생성물 1

HCID 444899Arachidonic Acid

실험 절차

The thus obtained acidic liquid was extracted 3 times with each 5 ml of ether, and after evaporating ether off from the ether extract, the dried solid was subjected to esterification by a diazomethane solution. The product of esterification was fractioned by thin layer chromatography while developing with a 90:50:20:100 by volume mixture of ethyl acetate, isooctane, acetic acid and water to obtained fractioned spots which were identified by the authentic specimens of PGD2, PGE2, PGF2α and 6-keto-PGF1α.

후처리

  1. extractionThe thus obtained acidic liquid was extracted 3 times with each 5 ml of ether
  2. customafter evaporating ether off from the ether
  3. extractionextract
  4. additionwhile developing with a 90:50:20:100 by volume mixture of ethyl acetate, isooctane, acetic acid and water
  5. customto obtained fractioned spots which

출처 및 근거

ORD 기록
ord-970a20277e544f4b819a8d970877b931
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05008243

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