Tributylstannane → 3-Cycloheptylpropanenitrile

HRID 1085070노트

반응식

HRID 1085070 반응식
Br[CH:2]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.CCCC[SnH](CCCC)CCCC.[C:22](#[N:25])[CH:23]=[CH2:24].CC(N=NC(C#N)(C)C)(C#N)C>C1(C)C=CC=CC=1>[CH:2]1([CH2:24][CH2:23][C:22]#[N:25])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

6

반응물 4

HCID 5948TributylstannaneHCID 6547AzobisisobutyronitrileHCID 7855AcrylonitrileHCID 16992Bromocycloheptane

생성물 1

HCID 131640453-Cycloheptylpropanenitrile

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

3-Cycloheptylpropionitrile is prepared in this example according to the procedure of Example 1 using a solution of 2-bromocycloheptane (25.57 g; 144.38 mmole); Bu3SnH (50.42 g; 173.26 mmole), acrylonitrile (15.32 g; 288.77 mmole), and AIBN (1.13 g) in toluene (300 ml). Yield is 16 g; mp oil.

출처 및 근거

ORD 기록
ord-8e7da019e32f41f4baaf4eadfa9ecce2
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05008265

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