Chlorosuccinimide → 5-Chloro-1-(4-cyanophenyl)-2-methylimidazole
반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])=[CH:5][CH:4]=1)#[N:2].[Cl:15]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Cl:15][C:13]1[N:9]([C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][CH:7]=2)[C:10]([CH3:14])=[N:11][CH:12]=1참가 물질
4
실험 절차
A solution of 1-(4-cyanophenyl)-2-methylimidazole (3 g, 16.4 mmol) and N-chlorosuccinimide (2.18 g, 16.3 mmol) in chloroform (180 ml) was heated at reflux for 4 hours, then washed with water, dried over magnesium sulphate and evaporated to a yellow solid. Trituration with ether left a pale-yellow solid (2.38 g, 67%).
후처리
- temperatureat reflux for 4 hours
- washwashed with water
- dry with materialdried over magnesium sulphate
- customevaporated to a yellow solid
- waitTrituration with ether left a pale-yellow solid (2.38 g, 67%)
출처 및 근거
- ORD 기록
- ord-8129d1d277e145ec8eda82bcf372b7db
- 출처 데이터셋
- uspto-grants-1991_04
- 특허 번호
- US05008263
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