Sodium Hydroxide → 1-Bromo-8-[3-(octadecyloxy)propoxy]octane

HRID 1085379

반응식

HRID 1085379 반응식
[CH2:1]([O:19][CH2:20][CH2:21][CH2:22][OH:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[Br:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]Br.[OH-].[Na+]>[Cl-].C([N+](C)(C)C)CCCCCCCCCCCCCCC>[Br:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][O:23][CH2:22][CH2:21][CH2:20][O:19][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 783101,8-DibromooctaneHCID 5553033-Octadecyloxypropanol

생성물 1

HCID 200621361-Bromo-8-[3-(octadecyloxy)propoxy]octane수율 53.1%

시약·촉매·용매 1

HCID 8154Hexadecyltrimethylammonium chloride촉매

실험 절차

Using 3-(octadecyloxy)propanol (5 g), 1,8-dibromooctane (12.7 g), cetyltrimethylammonium chloride (0.96 g) and a 50% aqueous solution of sodium hydroxide (12 g), a reaction is conducted in the same manner as that in Reference Example 4 to give the above-titled compound as colorless solid (4.2 g).

출처 및 근거

ORD 기록
ord-d58e6cf668b34430862db0e91b59ed26
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05008454

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