Hydrochloric Acid → 6-(4-Hydroxypiperidino)carbostyril hydrochloride

HRID 1085469노트

반응식

HRID 1085469 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1.[ClH:19]>CO>[ClH:19].[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 104669946-(4-Hydroxypiperidino)carbostyril

생성물 1

HCID 200601536-(4-Hydroxypiperidino)carbostyril hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

6-(4-Hydroxypiperidino)carbostyril, 0.1 g (0.002 mole), was suspended in 15 mL methanol. Five mL ethanolic hydrogen chloride was added and the mixture digested on a steam bath for 15 minutes until part of the methanol had evaporated. After cooling, filtration and washing with ethyl acetate, the resulting white crystals, 0.05 g, were recrystallized by dissolving in warm methanol and adding ethyl acetate. The yield was 0.05 g 6-(4-hydroxypiperidino)carbostyril hydrochloride; m.p. 259°-262° C.

후처리

  1. customhad evaporated
  2. temperatureAfter cooling
  3. filtrationfiltration
  4. washwashing with ethyl acetate
  5. customthe resulting white crystals, 0.05 g, were recrystallized
  6. dissolutionby dissolving in warm methanol
  7. additionadding ethyl acetate

출처 및 근거

ORD 기록
ord-4ca302c327e341f686b861e62fdd0b24
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05010088

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