Pyridine → 6-(4-acetoxypiperidino)-2(1H)-quinolinone

HRID 1085470노트

반응식

HRID 1085470 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1.[C:19](OC(=O)C)(=[O:21])[CH3:20].N1C=CC=CC=1.C(=O)(O)[O-].[Na+]>O>[C:19]([O:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13](=[O:18])[CH:12]=[CH:11]3)[CH2:4][CH2:3]1)(=[O:21])[CH3:20]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 104669946-(4-Hydroxypiperidino)carbostyril

생성물 1

HCID 200601526-(4-acetoxypiperidino)-2(1H)-quinolinone

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 6-(4-hydroxypiperidino)carbostyril (0.25 g), acetic anhydride (0.4 g) and dry pyridine (4 mL) was heated at 100° C. for 3 hours. The reaction mixture was cooled and water (about 35 mL) and sodium bicarbonate (0.6 g) were added. The mixture was chilled in ice and stirred. The resulting white solid was removed by filtration, washed with water and dried to give 6-(4-acetoxypiperidino)-2(1H)-quinolinone. 1/4 hydrate (0.3 g); m.p. 245°-250° C.

후처리

  1. temperatureThe reaction mixture was cooled
  2. temperatureThe mixture was chilled in ice
  3. customThe resulting white solid was removed by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b80b82fe7d2a4a3ebf85b1138c3e9ab5
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05010088

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