Benzyl Bromide → HCID 20059716, 화합물

HRID 1085551노트

반응식

HRID 1085551 반응식
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]([OH:12])=[O:11])=[C:4]([CH3:13])[CH:3]=1.[H-].[Na+].[CH2:16](Br)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CN(C)C=O>[CH2:16]([O:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]([CH2:9][C:10]([O:12][CH2:13][C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)=[O:11])=[C:6]([CH3:8])[CH:7]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 24758Sodium hydrideHCID 126604274-Hydroxy-2,6-dimethylbenzeneacetic acid

생성물 1

HCID 20059716HCID 20059716, 화합물수율 161.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.36 g of 2-(4-hydroxy-2,6-dimethylphenyl)acetic acid was treated with 184 mg of a 60% dispersion of sodium hydride in mineral oil and 0.72 g of benzyl bromide in 10 ml of dry dimethylformamide. The solvent was removed by evaporation and the residue was partitioned between water and methylene chloride. The organic layer was evaporated to give 0.63 g of crude product of melting point 54°-57° C. Recrystallization from aqueous methanol gave 0.58 g of pure benzyl 2-(4-benzyloxy-2.6-dimethylphenyl)acetate of melting point 62°-64° C.

후처리

  1. customThe solvent was removed by evaporation
  2. customthe residue was partitioned between water and methylene chloride
  3. customThe organic layer was evaporated
  4. customto give 0.63 g of crude product of melting point 54°-57° C
  5. customRecrystallization from aqueous methanol

출처 및 근거

ORD 기록
ord-b2af7a42e55841c9a65aff3f57137c49
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05010060

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