Water → 2-Amino-6-(4-chlorophenoxy)-4-fluoropyrimidine

HRID 1085887노트

반응식

HRID 1085887 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.[NH2:11][C:12]1[N:17]=[C:16](F)[CH:15]=[C:14]([F:19])[N:13]=1.O>CO.CN1CCCC1=O>[NH2:11][C:12]1[N:13]=[C:14]([F:19])[CH:15]=[C:16]([O:10][C:7]2[CH:8]=[CH:9][C:4]([Cl:3])=[CH:5][CH:6]=2)[N:17]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 46844-ChlorophenolHCID 14798Sodium HydroxideHCID 12014802-Amino-4,6-difluoropyrimidine

생성물 1

HCID 147172322-Amino-6-(4-chlorophenoxy)-4-fluoropyrimidine

시약·촉매·용매 2

HCID 887Methanol용매HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
140 °C

실험 절차

2.52 g (0.038 mol) of 85% sodium hydroxide were dissolved in 50 ml of methanol, 4.9 g (0.0382 mol) of 4-chlorophenol were added, and the mixture was evaporated to dryness. The residue of salt obtained in this way was taken up in 50 ml of N-methyl-2-pyrrolidone and, at 25° C., 5.0 g (0.0382 mol) of 2-amino-4,6-difluoropyrimidine were added, and the mixture was stirred at 140° C. for 4 hours. After the reaction mixture had been cooled to 25° C. it was stirred into 500 ml of water, and the resulting precipitate was isolated. 7.4 g (81% of theory) of the title compound of melting point 223°-226° C. were obtained in this way.

후처리

  1. customthe mixture was evaporated to dryness
  2. customThe residue of salt obtained in this way
  3. temperatureAfter the reaction mixture had been cooled to 25° C. it
  4. customthe resulting precipitate was isolated

출처 및 근거

ORD 기록
ord-7ece029aff1e468184a6961455c84fca
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011927

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