Acetic Acid → Npc182939

HRID 1085934

반응식

HRID 1085934 반응식
[CH3:1][C@H:2]1[C@@H:12]2[CH2:13][CH2:14][C@@:15]3([CH3:19])[O:17][O:18][C@:11]42[C@H:5]([C@@H:6]([CH3:20])[C:7]([O:9][C@@H:10]4[O:16]3)=[O:8])[CH2:4][CH2:3]1.[BH4-].[Na+].C(O)(=O)C>CO>[CH3:1][C@H:2]1[C@@H:12]2[CH2:13][CH2:14][C:15]3([CH3:19])[O:17][O:18][C@:11]42[C@H:5]([C@@H:6]([CH3:20])[C@@H:7]([OH:8])[O:9][C@@H:10]4[O:16]3)[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 68827ArtemisininHCID 4311764Sodium borohydride

생성물 1

HCID 456410Npc182939

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4 g (0.014 m) of qinghaosu (I) in 200 ml of methanol, was added 4 g of sodium borohydride in small portions, keeping the reaction mixture at 0°-5°. After stirring for 60 min, the mixture was neutralized with glacial acetic acid, concentrated and diluted with water. The white precipitate formed was collected and dried. Recrystallization of the solid from acetone-hexane afforded white needles mp: 153°-58° C., 3.2 g (80).

후처리

  1. customat 0°-5°
  2. concentrationconcentrated
  3. additiondiluted with water
  4. customThe white precipitate formed
  5. customwas collected
  6. customdried
  7. customRecrystallization of the solid from acetone-hexane afforded white needles mp: 153°-58° C., 3.2 g (80)

출처 및 근거

ORD 기록
ord-2dde5313947f46a090dca57632cbefff
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011951

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