4-Acetylpyridine → 4-Trifluoromethylbenzoic acid [1-(4pyridinyl)ethylidene]hydrazide

HRID 1085957

반응식

HRID 1085957 반응식
[C:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=O)[CH3:2].[F:10][C:11]([F:23])([F:22])[C:12]1[CH:21]=[CH:20][C:15]([C:16]([NH:18][NH2:19])=[O:17])=[CH:14][CH:13]=1>C(O)C>[N:7]1[CH:8]=[CH:9][C:4]([C:1](=[N:19][NH:18][C:16](=[O:17])[C:15]2[CH:14]=[CH:13][C:12]([C:11]([F:10])([F:23])[F:22])=[CH:21][CH:20]=2)[CH3:2])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 142824-AcetylpyridineHCID 5206624-(Trifluoromethyl)benzohydrazide

생성물 1

HCID 538678224-Trifluoromethylbenzoic acid [1-(4pyridinyl)ethylidene]hydrazide수율 84%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2.97 gm (0.0245 mole) of 4-acetylpyridine, 5.0 gm (0.0245 mole) of 4-trifluoromethylbenzhydrazide and 100 ml of absolute ethanol is refluxed for 6 hr. The hot solution is filtered. The filtrate is diluted with water to the cloud point, cooled to room temperature and chilled. The crystals which separate are collected, washed with water and dried to yield 6.29 gm (84%) of the title compound having a melting point of 198.4° C.

후처리

  1. temperatureis refluxed for 6 hr
  2. filtrationThe hot solution is filtered
  3. additionThe filtrate is diluted with water to the cloud point
  4. temperaturechilled
  5. customThe crystals which separate
  6. customare collected
  7. washwashed with water
  8. customdried

출처 및 근거

ORD 기록
ord-fa282594d35946fd91d63e933799e28c
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011932

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