Ethanol → 3-Trifluoromethylbenzoic acid [1-(3-pyridinyl)propylidene]hydrazide

HRID 1085970

반응식

HRID 1085970 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([NH:8][NH2:9])=[O:7].[CH2:15]([C:17]([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)=O)[CH3:16].C(O)C>C(O)(=O)C.O>[N:21]1[CH:22]=[CH:23][CH:24]=[C:19]([C:17](=[N:9][NH:8][C:6](=[O:7])[C:5]2[CH:10]=[CH:11][CH:12]=[C:3]([C:2]([F:13])([F:14])[F:1])[CH:4]=2)[CH2:15][CH3:16])[CH:20]=1

참가 물질

6

반응물 3

HCID 702EthanolHCID 740741-(3-Pyridyl)propan-1-oneHCID 27774173-(Trifluoromethyl)benzoic acid hydrazide

생성물 1

HCID 540455043-Trifluoromethylbenzoic acid [1-(3-pyridinyl)propylidene]hydrazide수율 74%

시약·촉매·용매 2

HCID 176Acetic Acid촉매HCID 962Water용매

실험 절차

A mixture of 10.21 gm (0.05 mole) of 3-trifluoromethylbenzoic acid hydrazide, 6.76 gm (0.05 mole) of ethyl-3-pyridyl ketone, 10 drops of glacial acetic acid and 100 ml of absolute ethanol was refluxed 15 hr. The reaction mixture was diluted with water to the cloud point and cooled to room temperature then chilled in the refrigerator. The solids that separated were collected, washed with Skellysolve B and dried to give 11.88 gm (74%) of product having a melting point of 119.4° C.

후처리

  1. temperaturewas refluxed 15 hr
  2. temperaturethen chilled in the refrigerator
  3. customThe solids that separated
  4. customwere collected
  5. washwashed with Skellysolve B
  6. customdried

출처 및 근거

ORD 기록
ord-2b4e538ebdce439b8fa05d5427632b7c
출처 데이터셋
uspto-grants-1991_04
특허 번호
US05011932

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